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Mio Nishizono's Locked-Room Murder Case (西園美魚密室殺人事件 Nishizono Mio Misshitsu Satsujin Jiken) is a Blu-ray Disc game that was released on the first volume of Blu-ray of Little Busters! Refrain on January 29, 2014. The game is in visual novel style similar to the original Little Busters!. It will be produced by Visual Art's. The story will be written by Leo Kashida and the art will be made by Na-Ga.

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